In order to prevent spam,
this email address cannot be copied.
Researcher Profile - Ilya Bezprozvanny Get Newsletter
Alzheimer Research Forum - Networking for a Cure Alzheimer Research Forum - Networking for a CureAlzheimer Research Forum - Networking for a Cure
  
What's New HomeContact UsHow to CiteGet NewsletterBecome a MemberLogin          
Papers of the Week
Current Papers
ARF Recommends
Milestone Papers
Search All Papers
Search Comments
News
Research News
Drug News
Conference News
Research
AD Hypotheses
  AlzSWAN
  Current Hypotheses
  Hypothesis Factory
Forums
  Live Discussions
  Virtual Conferences
  Interviews
Enabling Technologies
  Workshops
  Research Tools
Compendia
  AlzGene
  AlzRisk
  Antibodies
  Biomarkers
  Mutations
  Protocols
  Research Models
  Video Gallery
Resources
  Bulletin Boards
  Conference Calendar
  Grants
  Jobs
Early-Onset Familial AD
Overview
Diagnosis/Genetics
Research
News
Profiles
Clinics
Drug Development
Companies
Tutorial
Drugs in Clinical Trials
Disease Management
About Alzheimer's
  FAQs
Diagnosis
  Clinical Guidelines
  Tests
  Brain Banks
Treatment
  Drugs and Therapies
Caregiving
  Patient Care
  Support Directory
  AD Experiences
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
ARF Team
ARF Awards
Advisory Board
Sponsors
Partnerships
Fan Mail
Support Us
Return to Top
Home: Community: Researcher Profiles
Researcher Profile

RESEARCHER INFORMATION
First Name:Ilya
Last Name:Bezprozvanny
Title:Professor
Advanced Degrees:PhD
Affiliation:UT Southwestern Medical Center at Dallas
Department:Dept of Physiology
Street Address 1:5323 Harry Hines Blvd
Street Address 2:ND12.200AA
City:Dallas
State/Province:TX
Zip/Postal Code:75390-9040
Country/Territory:U.S.A.
Phone:214-645-6017
Email Address: 
Disclosure:
(view policy) 
Member reports no financial or other potential conflicts of interest. [Last Modified: 24 October 2008]
View all comments by Ilya Bezprozvanny
Clinical Interests:
Alzheimer Disease, Polyglutamine Disorders (Huntington's, etc.)
Work Sector(s):
University
Web Sites:
Lab: http://www4.utsouthwestern.edu/ilya
Researcher Bio
Please see http://myprofile.cos.com/ilya

Top Papers
1. Bezprozvanny I, Watras J, Ehrlich BE, Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum, Nature, 351(6329), 751-4, June 1991

2. Bezprozvanny I, Scheller RH, Tsien RW, Functional impact of syntaxin on gating of N-type and Q-type calcium channels, Nature, 378(6557), 623-6, December 1995

3.Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I, Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1, Neuron, 39(2), 227-39, July 2003

4. Tie-Shan Tang, Elizabeth Slow, Vitalie Lupu, Irina G. Stavrovskaya, Mutsuyuki Sugimori, Rodolfo Llinás, Bruce S. Kristal, Michael R. Hayden and Ilya Bezprozvanny (2005) Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. PNAS, v 102, pp 2602-2607

5. Huiping Tu, Omar Nelson, Arseny Bezprozvanny, Zhengnan Wang, Sheu-Fen Lee, Yi-Heng Hao, Lutgarde Serneels, Bart De Strooper, Gang Yu, and Ilya Bezprozvanny (2006) Presenilins form ER calcium leak channels, a function disrupted by familial Alzheimer’s disease-linked mutations. Cell, v 126, pp 981-993.

6. Omar Nelson, Huiping Tu, Tianhua Lei, Mostafa Bentahir, Bart de Strooper, and Ilya Bezprozvanny (2007) Familial Alzheimer’s disease-linked mutations specifically disrupt calcium leak function of presenilin 1. Journal of Clinical Investigation, vol. 117, pp. 1230-1239.

7. Tie-Shan Tang, Xi Chen, Jing Liu, and Ilya Bezprozvanny (2007) Dopaminergic signaling and striatal neurodegeneration in Huntington’s disease. Journal of Neuroscience, vol 27, pp. 7899-7910.

8. I. Bezprozvanny and M.R. Hayden (2004) Deranged neuronal calcium signaling and Huntington’s disease. Biochemical and Biophysical Research Communications, v. 322, pp 1310-1317.

9. Ilya Bezprozvanny and Mark P. Mattson (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer’s disease. Trends in Neuroscience, v. 31, pp 454-463
What is the greatest void to date in our knowledge of Alzheimer's Disease?
Clear cause and effect connection between disease-causing mutations and neurodegeneration. Development of animal models that recapitulate the progression of the diseasecorrely.
What is your leading hypothesis?
Neuronal calcium signaling plays a key role in neurodegenerative process.
What piece of missing evidence would help prove it?
Evaluation of calcium signaling blockers in mouse models and clinical trials.

Print this page
Email this page
Alzforum News
Papers of the Week
Text size
Share & Bookmark
Desperately

Antibodies
Cell Lines
Collaborators
Papers
Research Participants
Copyright © 1996-2013 Alzheimer Research Forum Terms of Use How to Cite Privacy Policy Disclaimer Disclosure Copyright
wma logoadadad